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Measurement of neopterin concentrations in urine can be performed by HPLC. In serum, plasma, cerebrospinal fluid or other protein-containing human body fluids, immunoassays like ELISA or RIA are preferable.




Soluble products of immune activation: Neopterin


Fuchs D, et al. Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria

(In: Manual of Clinical Laboratory Immunology. 4th Edition (Rose RR, deMacario EC, Fahey JL, Friedman H, Penn GM, editors), The American Society for Microbiology, Washington DC, 1992, 251-255)


Commercial enzyme-linked immunosorbent assay for neopterin detection in blood donations compared with RIA and HPLC.

Mayersbach P, et al. Central Inst. Blood Transfusion and Immunology, University Hospital, Innsbruck, Austria 

(Clin Chem 1994; 40: 265-266)


Evaluation of a new simple and rapid enzyme-linked immunosorbent assay kit for neopterin determination.

Westermann J, et al.
Immuno-Biological Laboratories GmbH, Hamburg, Germany
(Clin Chem Lab Med 2000; 38: 345-353.)

A new commercially available enzyme-linked immunosorbent assay (ELISA) kit has been evaluated for the measurement of neopterin concentrations in serum, plasma and urine. This competitive ELISA is technically simple, requires only small sample volume and is rapid to perform. The assay procedure consists of sequential 1.5 h and 10 min room temperature incubation steps. The ELISA is accurate, sensitive, specific, and precise. Linear regression analysis of neopterin concentrations measured with the new ELISA and with an established method yielded a highly significant correlation (r = 0.99). The new assay is applicable to ELISA workstations, thus enabling determination of neopterin in large series of samples. The neopterin ELISA kit has been used in routine laboratory testing of blood donations in a blood bank.